Keith Isaacson was born and raised in Atlanta, Georgia. He graduated cum laude from Tulane University with honors in biology in 1979 and attended medical school at the Medical College of Georgia. Dr. Isaacson finished his residency in Obstetrics and Gynecology at the Ochsner Clinic in New Orleans, LA. He then finished a fellowship in Reproductive Endocrinology and Infertility at the University of Pennsylvania. He is currently board certified in Reproductive Endocrinology and general Obstetrics and Gynecology.

Dr. Isaacson was the Division Director of Reproductive Endocrinology and Infertility at the Massachusetts General Hospital from 1991 until 2001. In the fall of 2001, he left to open a center for minimally invasive gynecologic surgery and infertility at Newton Wellesley Hospital. He is currently director of the residency and fellowship for minimally invasive gynecologic surgery and infertility. Dr Isaacson is the Co-Director of the Center for Gynepathology Research at the Massachusetts Institute of Technology.

Dr. Isaacson is the immediate past president of the Society of Reproductive Surgeons (SRS) and the past president of the American Association of Gynecologic Surgeons (AAGL). He is currently the President of the AAGL/SRS Fellowship Board of Directors and on the Board of Directors of the Society of Laparoscopic Surgeons. His recent awards include the Distinguished Surgeon Award from the American Society of Reproductive Medicine in 2013. Dr. Isaacson has focused his clinical career in advance hysteroscopic and laparoscopic procedures in women wishing to maintain their reproductive potential. He has over 75 peer reviewed publications, numerous textbook chapters and had edited two textbooks on laparoscopic and hysteroscopic surgery.