Submitted
2025 Global Health Challenge

Rypple

Team Leader
Daniela de Paiva
Rypple is a global health ecosystem hub that makes prevention practical, scalable, and investable. We work at the intersection of policy, innovation, and finance to help governments, businesses, and health innovators shift from reactive care to prevention-first systems. We operate through three core engines: • Policy Action Lab – We help governments design, model, and deliver prevention strategies. Our dynamic...
What is the name of your organization?
Rypple
What is the name of your solution?
Rypple
Provide a one-line summary or tagline for your solution.
Rypple powers the shift to prevention, combining tech, strategy, and cross-sector collaboration to scale upstream health innovation
In what city, town, or region is your solution team headquartered?
The Hague, Netherlands
In what country is your solution team headquartered?
NLD
What type of organization is your solution team?
Hybrid of for-profit and nonprofit
Film your elevator pitch.
What specific problem are you solving?
The global health system is built to treat disease, not sustain health. Most healthcare spending goes to reactive care, even though preventable conditions like non-communicable diseases account for over 60% of global deaths. Up to 30% of healthcare costs stem from over-treatment, half the world lacks access to essential services, and 100 million people are pushed into extreme poverty each year by health expenses. Healthcare systems worldwide remain reactive rather than proactive, leading to rising costs, inequitable access, and preventable health burdens. Most solutions focus on service delivery rather than systemic transformation, leaving governments and businesses struggling to adopt sustainable preventive health strategies. Financial incentives still favor disease management, while structural barriers—siloed funding, rigid procurement, fragmented data—block innovation and scale. Rypple exists to change that. As a global health ecosystem hub, we shape systems that reward prevention. Our Policy Action Lab helps governments model the impact of preventive interventions, shift funding priorities, and build local prevention markets. Our Business Innovation Base supports corporations to move beyond CSR and invest in prevention as strategy. We are building self-reinforcing ecosystems where staying healthy is the easier, more accessible, and economically viable choice.
What is your solution?
Rypple is a global health ecosystem hub that makes prevention practical, scalable, and investable. We work at the intersection of policy, innovation, and finance to help governments, businesses, and health innovators shift from reactive care to prevention-first systems. We operate through three core engines: • Policy Action Lab – We help governments design, model, and deliver prevention strategies. Our dynamic simulation tools integrate epidemiological, behavioral, and economic data to visualize the long-term impact and ROI of preventive interventions. We also embed in delivery teams, align financing, and co-create prevention markets—building the local infrastructure needed for solutions to thrive. • Business Innovation Base – We work with corporations, insurers, and health innovators to embed prevention into business strategy. This includes identifying prevention-aligned opportunities, co-developing products and services, and using modeling to support investment and pricing. • Predictive ROI Engine – Our platform uses AI and health economics to forecast disease trajectories, simulate policies, and calculate the return on investment of preventive actions in both human and economic terms. Rypple is the connective infrastructure that enables systemic change, so "health-ing" becomes the easier, more sustainable choice for all.
Who does your solution serve, and in what ways will the solution impact their lives?
Who does your solution serve, and in what ways will the solution impact their lives? Rypple serves governments, policymakers, businesses, insurers, and health innovators to drive systemic change in how health is valued and delivered—ultimately improving the lives of communities with limited access to preventive care. Primary beneficiaries: • Government agencies & policymakers use Rypple’s AI-powered modeling tools to estimate ROI on prevention, prioritize high-impact interventions, and design policies that shift spending from treatment to long-term health outcomes. • Corporate leaders integrate prevention into HR and ESG strategies, improving employee health and reducing absenteeism. Rypple also supports insurers in adjusting pricing models for companies that invest in prevention—creating incentives that reward proactive health. • Health innovators gain access to implementation pathways, procurement opportunities, and aligned funding to scale what works. • Underserved communities benefit from expanded access to preventive care through both public programs and private-sector channels. Impact: • Reduced disease burden and stronger, more equitable health outcomes • Cost savings across public and private health systems • New market opportunities for prevention-driven products and services • A redefined health economy where staying healthy pays—for everyone
Solution Team:
Daniela de Paiva
Daniela de Paiva
CEO